FORMULATION AND EVALUATION OF ANTI INFLAMMATORY SPRAY.

Abstract

The aim of this research was to formulate and evaluate anti-inflammatory spray, containing turmeric as a chief herbal drug for the treatment of inflammation. The spray  were formulated using extracts of Turmeric. Turmeric (curcumin)are used as anti-inflammatory agents, Menthol is used for relief pain, Turpentine oil used as  perfume/fragrance, Glycerol used as permeation enhancer and balancing pH, Ethyl alcohol analytical solvent and penetrating agent. 

The formulated spray were evaluated for parameter including Visual appearances (Color, Oduor, Transparency), pH, Viscosity ,Viscosity, Evaporation Time/Drying time, Stickiness of the spray after evaporating the solvent, Container related Evaluation: Spray angel, Short term stability study ,Efficiency of pump seal /Leak test 1) Immediate leak test, Stability Test and In Vitro Anti-Inflammatory activity by using the  Proteins denaturation  method and protein inhibition method. The physical parameter was found to be within acceptable limit The anti-inflammatory activity revealed the formulated spray has comparable anti-inflammatory activity as compared to standard drug diclofenac sodium ( 56.64% vs 64.16%)