"FORMULATION AND IN-VITRO EVALUATION OF TRIAMTERENE TRANSDERMAL PATCHES"

Abstract

Triamterene (2,4,7-triamino-6-phenylpteridine) is an antihypertensive drug used for the management of hypertension^31-32 and also for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and the nephritic syndrome; also in steroid induced edema, idiopathic edema, and edema due to secondary hyperaldosteronism.

Triamterene is commercially available in the form of capsules, after oral administration the drug, it undergo first pass metabolism which leads to poor bioavailability i.e. 30%³⁴. The poor Bioavailability of the drug can be improved by designing a new/ novel drug delivery system and designing of transdermal drug delivery system is one among them.

In the present research work, we have prepared transdermal patches of triamterene with an objective of  improved bioavailability by bypassing pre-systemic metabolism and as a result it improves therapeutic efficacy of the drug. Transdermal patches released the drug in a controlled manner for longer period of time which intern reduces the frequency of dosing which improves the patient compliance.